Study Detail

TitleComprehensive analysis of CRMs with RNA-seq data revealed that Lim1/Otx2-bound CRMs co-localizing with TLE rather than p300 are strongly associated with region/tissue-specific genes.
Study TypeTranscriptome Analysis
Abstract In vertebrates, homeodomain proteins Otx2 and Lim1/Lhx1 are required for head formation, but the regulatory principles underlying their functions in the head organizer remain unsolved. Here we show using ChIP-seq analysis that Otx2, Lim1, the coactivator p300 and the corepressor TLE/Groucho colocali .. [more]
Center NameUT_SCI