| Title | RNA stability defines the identity of long noncoding RNA in mammals |
| Study Type | Transcriptome Analysis |
| Abstract |
There is growing recognition that mammalian genomes produce huge number of long noncoding RNAs (ncRNAs). However, the biological functions of most long ncRNAs are still unclear. Here we report a new approach to uncover the discriminative property of the functional long ncRNAs by combination of compr .. [more]ehensively measuring the half-lives and functional analysis. Our approach reveals hundreds of short-lived ncRNAs in which many well-known functional long ncRNAs are sorted. Moreover, we provide strong evidence that modulation of half-lives of relatively short-lived functional long ncRNAs, viz. NEAT1/MEN ⋯ and GAS5, alters functional consequence, and identified novel short-lived intergenic noncoding transcripts (SLITs), those degradations are regulated by stimuli, involving in cell proliferation. Together, these results propose that short-lived property of ncRNA will be key parameter for identifying the uncharacterized long ncRNAs. [less]
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| Description |
There is growing recognition that mammalian genomes produce huge number of long noncoding RNAs (ncRNAs). However, the biological functions of most long ncRNAs are still unclear. Here we report a new approach to uncover the discriminative property of the functional long ncRNAs by combination of compr .. [more]ehensively measuring the half-lives and functional analysis. Our approach reveals hundreds of short-lived ncRNAs in which many well-known functional long ncRNAs are sorted. Moreover, we provide strong evidence that modulation of half-lives of relatively short-lived functional long ncRNAs, viz. NEAT1/MEN ⋯ and GAS5, alters functional consequence, and identified novel short-lived intergenic noncoding transcripts (SLITs), those degradations are regulated by stimuli, involving in cell proliferation. Together, these results propose that short-lived property of ncRNA will be key parameter for identifying the uncharacterized long ncRNAs. [less]
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| Center Name | UT-MGS |
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