| Description |
Although recent studies have revealed that the majority of human genes
are subjected to regulation of alternative promoters (APs), the biological relevance of
this phenomenon remains unclear. In order to understand biological significance of the
presence of diverg .. [more]ent transcription initiation events in the respective cell types, it
is indispensable to obtain bird-view of the transcriptome figures at every step of the
gene expression; namely, i) how the genomic structure change to transcriptionally active
form, ii) where the transcription initiation complex is recruited, iii) to what extent
the transcription is activated, iv) what transcripts formed and sorted to what
subcellular fractions. We have recently started multi-faceted use of the Illumina GA to
answer these questions. Integrative analysis produced for respective aspects of the gene
expression regulations revealed the comprehensive figures of the complex human gene
transcriptome for the first time. [less]
|
FTP
