| Project title | Establishment of a cell-based assay system for measuring the level of Masc-induced dosage compensation in silkworm cultured cells |
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| Project Description | The Masculinizer (Masc) gene encodes a CCCH-tandem zinc finger protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori (Lepidoptera: Bombycidae). We previously measured the masculinizing activity of the lepidopteran Masc proteins and their derivatives using B. mori ovary-derived cell line BmN-4. In this study, we newly established an RNA-seq data-based assay in which the level of B. mori Masc (BmMasc)-induced dosage compensation can be estimated in BmN-4 cells. |
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| Release Date | 2019-07-16 |
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Grant 1 |
| GrantId | JSPS KAKENHI Grant Number 15H02482 |
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| Agency abbreviation | JSPS |
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| Agency | Japan Society for the Promotion of Science |
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Grant 2 |
| GrantId | JSPS KAKENHI Grant Number 17H06431 |
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| Agency abbreviation | MEXT |
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| Agency | Ministry of Education, Culture, Sports, Science and Technology |
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Grant 3 |
| GrantId | JSPS KAKENHI Grant Number 16H06279 |
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| Agency abbreviation | MEXT |
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| Agency | Ministry of Education, Culture, Sports, Science and Technology |
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