Project Detail : PRJDB5053

AccessionPRJDB5053
Project TypePrimary submission
Project Data TypeExome

General info

Project titleEffect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines
Project Description
Effective molecular target drugs that improve therapeutic efficacy with fewer adverse effects for esophageal cancer are highly anticipated. Poly(ADP-ribose) polymerase (PARP) inhibitors have been proposed as low-toxicity agents to treat double strand break (DSB)-repair defective tumors. Several findings imply the potential relevance of DSB repair defects in the tumorigenesis of esophageal squamous cell carcinoma (ESCC). We evaluated the effect of a PARP Inhibitor (AZD2281) on the TE-series ESCC cell lines.
Release Date2018-07-29

Project Type

Sample scope/Material/Capture/Methodology

Sample ScopeMonoisolate
MaterialGenome
CaptureExome
MethodologySequencing

Objective

ObjectiveRawSequenceReads

Target

Organism information

Organism nameHomo sapiens
Taxonomy ID9606

Project Publication

Publication 1

DOI10.1111/cas.12322