Project Detail : PRJDB3044

AccessionPRJDB3044
Project TypePrimary submission
Project Data TypeEpigenomics

General info

Project titleIDENTIFICATION OF UNIQUE HISTONE MODIFICATION IN SLOW SKELETAL MUSCLE OF RATS
Project Description
Skeletal muscle is classified into fast and slow characteristics. Although numerous studies

reported the adaptation and transformation of muscle properties and phenotype in response to 

various stimuli, such as exercise, unloading and gene mutation models, the differences of the 

epigenetic background in these muscle types were unclear. Here, we demonstrate the major 

differences of histone modifications in fast plantaris and slow soleus of adult rats. Genome-wide 

ChIP-seq analysis revealed that transcriptionally active histone marks, tri-methylation at lysine 4 

and acetylation of histone 3, were less mapped at the genes activated specially in slow soleus, 

whereas the transcription of fast muscle-specific genes associated with these active histone marks in 

fast plantaris.
Release Date2016-06-14
RelevanceMedical

Project Type

Sample scope/Material/Capture/Methodology

Sample ScopeMonoisolate
MaterialPartialGenome
CaptureWhole
MethodologySequencing

Objective

ObjectiveRawSequenceReads

Target

Organism information

Organism nameRattus norvegicus
Taxonomy ID10116