Streptococcus pyogenes cause a wide variety of infectious diseases, from relatively benign to life threatening. S. pyogenes can be subtyped according to the serotypes of the M proteins expressed on the cell surface. Particular M types of GAS have been associated with certain diseases, which suggests that there are differences in the expression of pathogenic traits among S. pyogeneswith different M types. M1 and M3 S. pyogenes have been found predominantly in patients with streptococcal toxic shock syndrome (STSS), a life-threatening in Japan, the United States, and Europe S. pyogenes str. M3-b is one of the isolates derived from a patient of a STSS case. In this study, complete whole genome sequence of S. progenes str. M3-b to analyze genes related to the virulence.